Premade Library Screening

Service

Binder Discovery

Nanobody Discovery

Yeast Display VHH Discovery Service Immunogen Design & Production Premade Library Screening Phage Display Nanobody Discovery Service Animal Immunization

Peptide Discovery

Yeast Display Peptide Library Screening

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No. 99 Haiwang Road, Chengdu, Sichuan, China

+86 400 8677 715

service@nb-biolab.com

Premade Library Screening

We offer screening services based on a diverse collection of premade display libraries. These libraries support the discovery of binding molecules against a wide range of targets, including soluble proteins, receptors, and challenging antigens.

Our premade library screening service integrates optimized panning or FACS-based selection strategies with sequencing analysis to efficiently identify candidate binders for downstream applications.

When to Use Premade Library Screening

Premade library screening is an ideal approach when rapid binder discovery is required without the time and cost associated with animal immunization or custom library construction. This strategy is particularly suitable in the following scenarios:

Early-stage target validation

Quickly identify binding molecules to evaluate target feasibility before committing to full discovery campaigns.

Projects with tight timelines

When rapid turnaround is critical, premade libraries enable binder identification within weeks.

Non-immunogenic or toxic targets

Suitable for targets that are difficult to immunize in animals or may cause poor immune responses.

Challenging targets

Applicable for screening against difficult targets where traditional approaches may be limited.

Available Premade Libraries

We provide large naïve VHH libraries using PBMCs and spleens from more than 50 healthy nonimmunized Alpacas/Llamas/Camels separately.

Features

Large capacity: 109-1010 individual transformants with more than 90 % unique sequences

High insertion rate: The positive insert ratio was more than 99.99%.

Code	Description	Applications
AlpSDAb-P	Phage display based Naïve VHH Library from Alpaca	phage display library for screening
CamSDAb-P	Phage display based Naïve VHH Library from Camel	phage display library for screening
LiaSDAb-P	Phage display based Naïve VHH Library from Llama	phage display library for screening
CamSDAb-Y	Yeast display based Naïve VHH Library from Camel	yeast display library for screening

Screening Workflow

Premade Library Screening

VHH Binder Validation( optional)

Selected candidates can undergo preliminary validation to confirm target binding. Optional downstream characterization services are available for detailed analysis.

Typical validation approaches include:

ELISA-based binding assays

Flow cytometry binding analysis

Competitive binding assays

Functional assays (if applicable)

Typical Project Timeline

Package	Service Step	Deliverables	Timeline
Basic	Library screening	Enriched binder sequences and screening report	2–4 weeks
Optional	Candidate production	Expression-ready constructs and VHH antibodies	2 weeks
Optional	Binder validation	Binding confirmation and functional data	1–2 weeks

Binder discovery can be completed within 2–4 weeks using premade libraries, significantly faster than traditional immunization-based approaches.

Advantages of Premade Library Screening

No need for animal immunization

Flexible screening strategies (panning or FACS)

Suitable for a wide range of targets

Rapid identification of candidate binders

Why Choose Our Premade Library Screening Service

Rapid Turnaround

Premade libraries eliminate the need for library construction, enabling fast project initiation and completion.

Diverse Library Resources

We provide access to multiple validated libraries covering antibody fragments and peptides.

Flexible Screening Platforms

Screening can be performed using phage display or yeast display depending on project needs.

Experienced Scientific Team

Our scientists have extensive experience in display technologies and binder discovery.

FAQs

What are the advantages of your company's natural single-domain antibody library?

The advantages of our natural single-domain antibody library are as follows:
1. Diverse species sources, covering PBMCs from three hosts: camel, llama and alpaca;
2. Library capacity reaches the 10¹¹ level, with unique sequence proportion over 90%;
3. Target fragment insertion rate of the library is as high as 99%;
4. Both phage library and yeast display library are available for parallel screening.

When should a natural library be selected for single-domain antibody screening?

Natural library screening is applicable for difficult-to-immunize targets with high homology to alpacas/camels that cannot induce effective immune responses. It is also suitable for projects with low requirements on antibody affinity.